New Mexico Molecular Libraries Screening Center


The New Mexico Molecular Libraries Screening Center is part of the Molecular Libraries Initiative within the overall NIH Roadmap.

Project Overview

PI: SKLAR, LARRY A. (lsklar at salud.unm.edu)
Grant Number: 1U54MH074425-01PI
Project Title: New Mexico Molecular Libraries Screening Center
Abstract:
We have developed innovative flow cytometric tools for discovery research that enable homogeneous analysis of ligand binding and protein-protein interaction, HT sample handling, high content analysis, and real-time measurements of cell response. more...

New Mexico MLSC Inventory/Capabilities


Space

The NM MLSC occupies and has available the following contiguous space on the second floor of UNM Cancer Research Facility:
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Equipment

1. Assay Development / Adaptation (AD/A):
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2. High Throughput Screening / Implementation (HTS/I):
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3. Screening Informatics (SI):
Computational resources - the machines are named after chili peppers:
  • "Chilaca" - 16x2 AMD Opteron processors with 1MB L2 Cache, 16x2 GB RAM memory and 16x250 GB SATA (4 TB) hard drives on master plus 15x80 GB on each node
  • "Chiltepin" - 4 AMD Opteron 846 processors, 32 GB RAM memory, 12x400 GB SATA 7200 RPM hard drives
more...

Center Expertise

Cellular Assays:

G protein-coupled receptors; Integrins and adhesion molecules; Proteases/proteasome; Cell cycle; Apoptosis

Bead-based assays:

Protein-protein interactions; Protein-nucleic acid interactions; Kinase assays

Informatics:

State-of-the-art, innovative tools for ligand-based and structure-based virtual screening; Unique tools for post-HTS analyses, clustering and in silico profiling; High performance tools for bioinformatics analyses; Unique data archiving and data mining capabilities; Tools to evaluate post-HTS analyses

Capacity

Projected: 5,000-10,000 wells per day per detector

MOLECULAR LIBRARIES INITIATIVE - SCREENING CENTERS

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